Motif ID: RXR{A,B,G}.p2

Z-value: 1.471


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRBhg19_v1_chr6_-_33168163_33168253-0.481.4e-05Click!
RXRGhg19_v1_chr1_-_165414499_165414591-0.333.9e-03Click!
RXRAhg19_v1_chr9_+_137218324_1372184770.065.9e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_140008956 8.456 DPP7
dipeptidyl-peptidase 7
chr19_+_49622480 6.621 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr5_+_92920592 6.579 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr19_+_1776117 6.145


chrX_+_30233674 6.092 NM_002364
MAGEB2
melanoma antigen family B, 2
chr19_+_1753661 5.546 NM_001080488
ONECUT3
one cut homeobox 3
chr1_-_212873306 5.432 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr6_+_43737937 5.411 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr16_+_3014216 5.313 NM_001253725
NM_001253726
NM_024507
NM_172229
KREMEN2



kringle containing transmembrane protein 2



chr6_+_43738394 4.997 VEGFA
vascular endothelial growth factor A
chr15_-_74495093 4.997 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr5_-_172755418 4.619 STC2
stanniocalcin 2
chr5_-_172755195 4.519 STC2
stanniocalcin 2
chr14_-_61190458 4.397 NM_017420
SIX4
SIX homeobox 4
chr15_-_74494851 4.213 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr1_-_212873197 4.088 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr15_-_74494780 4.075 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr6_+_43738177 4.048 VEGFA
vascular endothelial growth factor A
chr12_-_48152180 3.934 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr16_+_71879858 3.868


chr22_+_50624353 3.812 NM_025204
TRABD
TraB domain containing
chr11_+_73087670 3.754 NM_032871
RELT
RELT tumor necrosis factor receptor
chr20_+_43343884 3.701 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr7_-_767286 3.642 NM_001164758
NM_001164759
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr19_+_18530423 3.639


chr19_+_54371150 3.631 MYADM
myeloid-associated differentiation marker
chr19_-_47922738 3.563 NM_001009813
NM_020160
MEIS3

Meis homeobox 3

chr2_+_233243243 3.507 NM_001632
ALPP
alkaline phosphatase, placental
chr11_-_2018446 3.486 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_81037504 3.484 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr4_+_1005395 3.431 FGFRL1
fibroblast growth factor receptor-like 1
chr1_+_226736603 3.356 C1orf95
chromosome 1 open reading frame 95
chr9_+_131185129 3.334 CERCAM
cerebral endothelial cell adhesion molecule
chr22_+_50624267 3.323 TRABD
TraB domain containing
chr11_-_2017822 3.290 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_-_56035176 3.286 NM_173814
PRTG
protogenin
chr6_+_24495016 3.271 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr19_-_56632644 3.269 NM_001002836
ZNF787
zinc finger protein 787
chr19_+_50354417 3.228 PTOV1
prostate tumor overexpressed 1
chr6_+_24495166 3.204 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr9_-_140009158 3.194 DPP7
dipeptidyl-peptidase 7
chr10_-_17496345 3.180 ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr20_-_36793646 3.132 NM_004613
NM_198951
TGM2

transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

chr16_+_718080 3.131 NM_138769
RHOT2
ras homolog gene family, member T2
chr6_+_43738757 3.125 VEGFA
vascular endothelial growth factor A
chr16_+_89213915 3.093


chr19_-_45873839 3.061 NM_000400
NM_001130867
ERCC2

excision repair cross-complementing rodent repair deficiency, complementation group 2

chr8_-_29206321 3.051 NM_057158
DUSP4
dual specificity phosphatase 4
chr11_-_2018334 3.017 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_-_55791446 2.985 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_-_55895602 2.975 NM_001190764
TMEM238
transmembrane protein 238
chr19_-_45873641 2.939 ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
chr19_+_6361462 2.928 NM_006012
CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chr11_-_65430545 2.854


chr6_+_29894105 2.839


chr11_+_65405538 2.824 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr6_-_3227776 2.812 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr5_+_139493689 2.773 NM_005859
PURA
purine-rich element binding protein A
chr16_+_71879893 2.770 NM_001137675
ATXN1L
ataxin 1-like
chr19_-_42759279 2.757 NM_006494
ERF
Ets2 repressor factor
chr9_-_139334274 2.719 INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr19_-_42759151 2.712 ERF
Ets2 repressor factor
chr19_-_55791428 2.684 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr4_+_140222668 2.662 NM_057175
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr19_+_54372659 2.661 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr19_+_48898131 2.659 NM_000836
GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
chr7_-_48019210 2.643 NM_004507
HUS1
HUS1 checkpoint homolog (S. pombe)
chr12_+_89744714 2.638 LOC100131490
uncharacterized LOC100131490
chr5_-_114515733 2.629 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr9_-_140009167 2.624 DPP7
dipeptidyl-peptidase 7
chr11_+_62439120 2.607 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr19_+_54371125 2.595 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr19_+_50354368 2.589 NM_017432
PTOV1
prostate tumor overexpressed 1
chr19_+_54371170 2.587 MYADM
myeloid-associated differentiation marker
chr10_+_97804149 2.573


chr1_-_153919140 2.551 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr19_+_11998609 2.508 NM_021915
ZNF69
zinc finger protein 69
chr11_+_62439134 2.501 C11orf83
chromosome 11 open reading frame 83
chr9_-_128003348 2.494 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr18_+_77160243 2.483 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr17_+_1958354 2.479 NM_006497
HIC1
hypermethylated in cancer 1
chr12_-_49318663 2.472 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_+_6361558 2.464 CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chrX_+_149531439 2.462 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr11_-_61684981 2.452 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr12_-_109251271 2.433 SSH1
slingshot homolog 1 (Drosophila)
chr20_+_43344005 2.425 WISP2
WNT1 inducible signaling pathway protein 2
chr19_+_54606141 2.417 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chrX_-_130964633 2.416 LOC286467
family with sequence similarity 195, member A pseudogene
chr19_-_47922339 2.407 MEIS3
Meis homeobox 3
chr3_-_50360109 2.386 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr17_+_36861857 2.377 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_55996537 2.335 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr19_+_17830302 2.296 NM_018174
MAP1S
microtubule-associated protein 1S
chr19_-_59069747 2.286 UBE2M
ubiquitin-conjugating enzyme E2M
chr12_+_65672422 2.273 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr19_-_46148606 2.267 NM_001193268
EML2
echinoderm microtubule associated protein like 2
chr11_+_128563772 2.267 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr9_+_116930778 2.258 COL27A1
collagen, type XXVII, alpha 1
chr9_+_35792405 2.236 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr4_+_140222620 2.234 NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr19_-_7990974 2.231 NM_206833
CTXN1
cortexin 1
chr11_+_67806517 2.202 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr14_-_61191027 2.195 SIX4
SIX homeobox 4
chr19_+_45251933 2.186 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr7_+_143078399 2.178 ZYX
zyxin
chr12_-_133306531 2.174 ANKLE2
ankyrin repeat and LEM domain containing 2
chr1_-_92951593 2.155 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr1_+_19972259 2.123 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr16_-_85784628 2.119 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr15_+_41221530 2.116 NM_019074
DLL4
delta-like 4 (Drosophila)
chr19_+_54695103 2.111 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr22_-_39640956 2.110 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr17_-_3627073 2.091 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr17_-_80291903 2.087 NM_003004
SECTM1
secreted and transmembrane 1
chr9_-_128003615 2.085 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr19_-_47922468 2.083 MEIS3
Meis homeobox 3
chr11_-_129872719 2.073 NM_020228
NM_199437
PRDM10

PR domain containing 10

chr11_+_450260 2.067 NM_030783
PTDSS2
phosphatidylserine synthase 2
chr1_+_101702304 2.064 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr12_+_132413743 2.054 NM_001002020
PUS1
pseudouridylate synthase 1
chr9_-_140353612 2.053 NELF
nasal embryonic LHRH factor
chr12_-_109251333 2.024 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr19_+_39390567 2.020 NM_002503
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr9_-_140009169 1.998 DPP7
dipeptidyl-peptidase 7
chr17_-_39222126 1.987 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr7_+_143078608 1.985 ZYX
zyxin
chr9_-_140009162 1.981 DPP7
dipeptidyl-peptidase 7
chr19_-_1020995 1.981 C19orf6
chromosome 19 open reading frame 6
chr1_-_155947898 1.975 NM_004723
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_+_157802479 1.964 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr11_+_450346 1.961 PTDSS2
phosphatidylserine synthase 2
chr19_-_47922391 1.955 MEIS3
Meis homeobox 3
chr9_+_35489989 1.937 NM_014806
RUSC2
RUN and SH3 domain containing 2
chr17_-_39203423 1.937 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chrX_+_153665468 1.936 GDI1
GDP dissociation inhibitor 1
chr19_+_39616384 1.929 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr2_+_10443825 1.928 NM_134421
HPCAL1
hippocalcin-like 1
chr9_-_140009171 1.922 DPP7
dipeptidyl-peptidase 7
chr8_+_145691702 1.920 NM_145754
KIFC2
kinesin family member C2
chr8_-_133493003 1.916 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr17_-_39211462 1.913 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr16_+_89778242 1.908 LOC100128881
uncharacterized LOC100128881
chr7_-_5567929 1.900 ACTB
actin, beta
chr19_-_1174201 1.896


chr11_+_450408 1.888 PTDSS2
phosphatidylserine synthase 2
chr11_+_560868 1.887 NM_001143993
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr19_-_13068033 1.883 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr19_+_10362598 1.879 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr19_+_56186569 1.876 EPN1
epsin 1
chr1_+_1243971 1.873 NM_153339
PUSL1
pseudouridylate synthase-like 1
chr11_+_12308446 1.865 NM_032867
MICALCL
MICAL C-terminal like
chr19_-_47354060 1.863 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr9_+_35490018 1.861 RUSC2
RUN and SH3 domain containing 2
chr16_-_73092533 1.859 NM_001164766
ZFHX3
zinc finger homeobox 3
chr10_-_77161539 1.842 ZNF503
zinc finger protein 503
chr19_+_6372443 1.837 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr19_-_38714781 1.826 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr10_+_88718287 1.809 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr12_+_65672682 1.808 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr8_+_145722108 1.807 NM_032902
PPP1R16A
protein phosphatase 1, regulatory subunit 16A
chr19_+_56186580 1.807 EPN1
epsin 1
chr7_+_143078444 1.806 ZYX
zyxin
chr12_-_89746244 1.802 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr7_+_143078447 1.798 ZYX
zyxin
chr1_+_9648931 1.797 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr19_-_1174263 1.793 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr12_-_89745753 1.787 DUSP6
dual specificity phosphatase 6
chr7_-_5553305 1.787 NM_024963
FBXL18
F-box and leucine-rich repeat protein 18
chr3_-_125655881 1.785 NM_001015050
NM_001195223
ALG1L

asparagine-linked glycosylation 1-like

chr12_-_89745997 1.783 DUSP6
dual specificity phosphatase 6
chr5_-_92916924 1.778 FLJ42709
uncharacterized LOC441094
chr15_+_62682682 1.778 TLN2
talin 2
chr20_+_60174816 1.772 NM_001252339
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr16_+_5121809 1.766 NM_019109
ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chr1_+_101702561 1.766 S1PR1
sphingosine-1-phosphate receptor 1
chr7_-_48019115 1.764 HUS1
HUS1 checkpoint homolog (S. pombe)
chrX_-_71526583 1.750 NM_004143
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr12_+_54378929 1.745 NM_017409
HOXC10
homeobox C10
chr8_-_145027975 1.732 NM_201379
PLEC
plectin
chr9_+_139780974 1.721 TRAF2
TNF receptor-associated factor 2
chr19_-_47249708 1.716 NM_001039877
NM_013403
STRN4

striatin, calmodulin binding protein 4

chr19_-_50432679 1.715 NUP62
IL4I1
nucleoporin 62kDa
interleukin 4 induced 1
chr7_-_766875 1.714 NM_001164760
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr10_+_123872440 1.710 TACC2
transforming, acidic coiled-coil containing protein 2
chr19_+_56186426 1.708 NM_001130072
NM_013333
EPN1

epsin 1

chr11_+_45825873 1.702 SLC35C1
solute carrier family 35, member C1
chr16_+_718157 1.694 RHOT2
ras homolog gene family, member T2
chr20_+_35234077 1.689 NM_001199534
NM_018840
NM_199483
C20orf24


chromosome 20 open reading frame 24


chr11_+_10326618 1.688 NM_001124
ADM
adrenomedullin
chr18_-_21242592 1.687 NM_173505
ANKRD29
ankyrin repeat domain 29
chr14_-_89020888 1.686 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr19_-_50432731 1.678 NUP62
nucleoporin 62kDa
chr17_+_72832064 1.677 TMEM104
transmembrane protein 104
chr1_-_155881063 1.667 RIT1
Ras-like without CAAX 1
chr19_-_1174257 1.661 SBNO2
strawberry notch homolog 2 (Drosophila)
chr3_-_122102057 1.657 NM_001017928
CCDC58
coiled-coil domain containing 58
chr19_-_50432678 1.656 NUP62
nucleoporin 62kDa
chr17_-_2614926 1.639 NM_015229
KIAA0664
KIAA0664
chr19_-_46000159 1.634 NM_005619
NM_206900
RTN2

reticulon 2


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
16.86 2.47e-03 GO:0005161 platelet-derived growth factor receptor binding